The aim of this new team is to federate within TIMC the actors of biomechanics of living tissues and materials for the living in order to give a better national and international visibility to these competences specific to our research laboratory. The activities conducted by the researchers of this team have for the most part applicative purposes (clinical assistance and design of medical devices for the living) involving both theoretical (modeling of the behavior of biological tissues and architectural materials), computational (numerical simulation) and experimental (characterization of materials, in vivo or post-mortem measurements) aspects.
The strength of the team is to be able to couple all these themes on the same scientific project.
The scientific research themes of the team are articulated around four research axes:
- The experimental characterization ex vivo and in vivo of the laws of behavior of living tissues and materials for the living (figure 1).
- The proposal of new laws of behavior adapted to the studied tissues and materials, with the permanent concern of proposing laws whose parameters can be characterized experimentally.
- Numerical simulation of living tissues and materials (figure 2), taking into account the specific anatomy of the patient and proposing solutions for routine clinical use (generation of patient-specific models, acceleration of calculations via model reduction techniques).
- Transfer to the clinic, with evaluations on patients via clinical studies.
Figure 1 : Ex vivo (left) and in vivo (center) characterization of lingual soft tissue.
Characterization of the vascular wall (right) from intravascular ultrasound sequences.
- Thierry Alonso (PRAG)
- Grégory Chagnon (Enseignant chercheur)
- Nathanaël Connesson (Enseignant chercheur)
- Denis Favier (Enseignant chercheur)
- Jean-Louis Martiel (Chercheur)
- Jacques Ohayon (Enseignant chercheur)
- Yohan Payan (Chercheur)
- Jérôme Tonetti (Enseignant chercheur)
- Mohamed Chetoui (ATER)
- Marouane El-Mouss (Visiteur)
- Elaheh Elyasi (Chercheur contractuel)
- Nolwenn Fougeron (Chercheur contractuel)
- Edouard Girard (Collaborateur hospitalier)
- Antoine Perrier (Collaborateur hospitalier)
The mechanical behavior of human organs and soft tissues is often very complex, since it is non-linear, time-varying, active, non-homogeneous and anisotropic. Any experimental mechanical characterization of such tissues (and even of materials interacting with these tissues) relies on behavioral models that best take into account this mechanical/geometrical/physical complexity. The researchers of the Biomeca-TIMC team determine behavioral laws (hyperelastic, viscoelastic, plastic or poroelastic) able to mimic the deformations undergone by human tissues and/or materials interacting with these tissues. We also propose original models for active tissues (e.g. muscle activation in interaction with bone segments, deformation of active organs such as the heart, the tongue or facial soft tissues).
The models developed are multi-scale (time and space) and multi-process (chemistry, cells, tissues, mechanics of continuous media). Their coupling with the environment can be done via equivalent boundary conditions (representative elementary volumes) to limit the complexity of the model itself. The team collaborates with several clinical services, with laboratories of chemistry, materials and biomechanics, as well as with industrial companies (startups and large groups).
Figure 2 : Simulations numériques des déformations du sein (gauche) et de plaques d’athérome (droite)
- Positioning within the biomechanics community: Y. Payan (2012) and J. Ohayon (2016) recipients of the Society of Biomechanics (SB) Senior Award; J. Ohayon past president of the SB; Y. Payan associate editor of the journal Clinical Biomechanics from 2020; J. Ohayon and Y. Payan editors of the series Biomechanics of Living Organs published by Elsevier (from 2017).
- International partnerships: UK, Iran, Canada, USA, Spain, Netherlands, Czech Republic, New Zealand, Israel.
- Wide spectrum of tissues modeled: cell, coronary vessels, muscles, fat, brain, face, tongue, breast, lungs, heart, liver, intestines, buttocks, prostate, urethra, knee, spine and foot.
Clinical and industrial valorization
The clinical and industrial valorization of the results is also a central objective of the team.
The researchers already have important collaborations with several clinical services in France and abroad, and in particular a privileged partnership with the Laboratory of Anatomy of the University Hospital of Grenoble.
Industrial valorization is achieved through the filing of patents (4 patents filed over the period 2014-219), industrial contracts (General Electric, ANSYS, Sinclair, Anatoscope, Uromems, Demeure Orthopédie) and transfers via the pre-maturation of the Institut CARNOT LSI (CARDIO and IFEM projects), maturation in SATT (IPAV project) and the creation of startups (Texisense and TwinSight).