MAGe

Models and Algorithms for Genomics

 

According to the geneticist Theodozius Dobzhansky (1973), nothing in biology makes sense except in the light of evolution. A current version of this quotation could add a light of genomics, the revolution of the 21rst century in the biological field. How not to see the dramatic progress and the implication of genomics for medicine, for the study of cancers, infections by pathogens, genetic or environmental diseases, associated treatments, etc.

By developing models and methods for the analysis of genomic data (in the broad sense), the MAGE group is part of the radical transformation of biological sciences and their fusion with computational sciences and mathematics. The team is strongly interdisciplinary, composed of biologists and mathematicians mastering the multiple facets of computational biology. The team objectives include four major areas of research, and new computational themes.

 

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Key-words

Computational Biology, Mathematical Models for Biology and Health, Evolutionary Biology and Ecology, Cancer, Male Infertility, Genomics, Epigenetics, Metagenomics

 

Scientific theme and general objectives

Computer and statistical models for the analysis of methylomes, metagenomes, transcriptomes, in order to answer biological, ecological and clinical questions.

 

Research topics

  • Analysis of genetic and epigenetic deregulations in cancers: characterization of inter- and intra-tumor heterogeneity (PI: Magali Richard).
  • Environmental genomics and epigenetics: mediation of environmental exposures, predictive molecular ecology (PI: Olivier François).
  • Evolution of microorganisms and metagenomics: competition and innovation in bacterial communities (PI: Antoine Frénoy).
  • Bioinformatics of NGS data: exome-seq, rip-seq, CNVs, call for genotypes and applications to male infertility (PI: Nicolas Thierry-Mieg).
  • Any other axis welcome!
 

Current members

AMBLARD Elise

BRACIS Chloe

DEBBAH Nagi

DESCAMPS Clémentine

FRANCOIS Olivier

FRENOY Antoine

GAIN Clément

JUMENTIER Basile

RICHARD Magali

SEPTIER Amandine

THIERRY-MIEG Nicolas

TURCHI Laura

 

Master  Students

PITTION Florence

WAGLE Manoj

 

Collaborations

IAB

IRD Montpellier

Inserm

LECA

LJK

Inria


Current research programs

COMETH (EIT Health). Characterization of intra-tumor heterogeneity in pancreatic cancer.

ETAPE (ANR-18-CE36-0005), SMOKE P3 (INCA-IRESP). Prenatal exposure to tobacco consumption and effects on child health: role of placental methylation.

MIM-REG (CNRS) Integrative modeling for the prediction of transcriptional regulations.

TRAGICOMIC (IRS - UGA) Gene transfer, innovation and competition in microbial communities.

FLAGELOMA (ANR-19-CE17-0014) Fundamental, genetic and clinical aspects of male infertility caused by severe abnormalities of the sperm flagella.

 

Teaching

Ensimag Grenoble INP

Master MSIAM Biologie Computationnelle