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A consensus approach for estimating health risk: Application to inhalation cancer risks

Pascal Petit 1 Anne Maître 1 Dominique Bicout 1
1 TIMC-EPSP - Environnement et Prévention en Santé des Populations
TIMC - Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525
Abstract : Conducting a risk assessment is challenging because various and contrasting risk indicators are available, which can lead to discrepancies and, sometimes, conflicting conclusions. Constructing and using a consensus risk indicator (CRI) could provide a reliable alternative that is consistent and supports direct comparisons. The goal of this study is to propose a structured and pragmatic approach for constructing a CRI distribution and demonstrate its feasibility and easy implementation when conducting risk assessments. A CRI distribution is constructed as a weighted combination of existing indicators where the weights are obtained by using the overlapping areas of an individual indicator's distribution and an aggregated reference distribution. The approach is illustrated through an assessment of human cancer risk following inhalation exposure. The CRI is constructed using eight risk indicators. The CRI distribution parameters for 199 human carcinogenic chemicals associated with inhalation exposure were determined and are presented in an interactive table. To aid the wider implementation of the CRI approach, a user-friendly and interactive web application, named InCaRisk, was created to facilitate the cancer risk estimation following inhalation exposure. Our approach could be useful for enhancing the quality of regulatory decisions and protecting human health from environmental pollutants; our approach can be applied for a given health outcome, route of exposure and exposure setting.
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https://hal.univ-grenoble-alpes.fr/hal-03364366
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Soumis le : lundi 4 octobre 2021 - 15:57:55
Dernière modification le : mardi 19 octobre 2021 - 11:06:02

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Pascal Petit, Anne Maître, Dominique Bicout. A consensus approach for estimating health risk: Application to inhalation cancer risks. Environmental Research, Elsevier, 2021, 196, pp.110436. ⟨10.1016/j.envres.2020.110436⟩. ⟨hal-03364366⟩

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