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Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study - Archive ouverte HAL
Article Dans Une Revue Allergy Année : 2021

Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study

Emek Kocatürk
Mona Al-Ahmad
  • Fonction : Auteur
Karoline Krause
Ana Gimenez-Arnau
Simon Francis Thomsen
Niall Conlon
  • Fonction : Auteur
Alexander Marsland
  • Fonction : Auteur
Ekin Savk
  • Fonction : Auteur
Roberta Criado
Inna Danilycheva
  • Fonction : Auteur
Daria Fomina
  • Fonction : Auteur
Kiran Godse
  • Fonction : Auteur
Maryam Khoshkhui
  • Fonction : Auteur
Aslı Gelincik
Ece Nur Degirmentepe
  • Fonction : Auteur
Semra Demir
Luis Felipe Ensina
  • Fonction : Auteur
Alicja Kasperska-Zajac
Michael Rudenko
  • Fonction : Auteur
Solange Valle
  • Fonction : Auteur
Iris Medina
  • Fonction : Auteur
Andrea Bauer
  • Fonction : Auteur
Zuotao Zhao
  • Fonction : Auteur
Petra Staubach
  • Fonction : Auteur
Özlem Su Küçük
  • Fonction : Auteur
Can Ateş
  • Fonction : Auteur
Marcus Maurer

Résumé

Abstract Background Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown. Aim To analyze the course and features of CU during and after pregnancy. Patients and methods PREG‐CU is an international, multicenter study of the Urticaria Centers of Reference and Excellence (UCARE) network. Data were collected via a 47‐item questionnaire completed by CU patients, who became pregnant within the last 3 years. Results A total of 288 pregnancies of 288 CU patients from 13 countries were analyzed (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ± 74.5 months; CSU 66.9%, CSU + CIndU 20.3%, CIndU 12.8%).During pregnancy, 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged.CU exacerbations most commonly occurred exclusively during the third trimester (in 34 of 124 patients; 27.6%) or the first (28 of 124; 22.8%). The risk factors for worsening of CU during pregnancy were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy, and stress as a driver of exacerbations. After giving birth, urticaria disease activity remained unchanged in 43.8% of CU patients, whereas 37.4% and 18.1% experienced worsening and improvement, respectively. Conclusions These results demonstrate the complex impact of pregnancy on the course of CU and help to better counsel patients who want to become pregnant and to manage CU during pregnancy.

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Dates et versions

hal-04997681 , version 1 (19-03-2025)

Identifiants

Citer

Emek Kocatürk, Mona Al-Ahmad, Karoline Krause, Ana Gimenez-Arnau, Simon Francis Thomsen, et al.. Effects of pregnancy on chronic urticaria: Results of the PREG‐CU UCARE study. Allergy, 2021, 76 (10), pp.3133-3144. ⟨10.1111/all.14950⟩. ⟨hal-04997681⟩
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