" Characterization of adaptive regulatory mutations
affecting DNA topoly-related genes
in the Long Term Experiment with E. coli "
 

Context:

The research team TIMC TrEE is interested in the evolutionary mechanisms involved in the adaptation of microorganisms to their environment, from in vitro culture  to their eukaryotic hosts (including  human hosts). One of the research topic deals with the Evolution of the structure and expression of (meta)-genomes, which aims at investigating the genomic determinants responsible for the remarkable adaptive properties of microorganisms (archaea and bacteria).
The internship will take place in the context of the Long-Term Evolution Experiment (LTEE), during which Escherichia coli populations have been propagated for more than 70 000 generations.
--- visit TIMC TrEE website
 

Internship background and objectives:

Skills:

 - Basic computational handling and analysis of metagenomic data
 - Basic know-how to test for bacterial phenotypes

• Place:  TIMC - UMR 5525, Domaine de la Merci, La Tronche
• Duration:  6 months
• Beginning:  near January 2022
   
• Contacts:  thomas.hindre [at] univ-grenoble-alpes.fr (Thomas Hindré)  &  ivan.junier [at] univ-grenoble-alpes.fr (Ivan Junier)