Searching for the Metabolic Signature of Cancer: A Review from Warburg’s Time to Now - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomolecules Année : 2022

Searching for the Metabolic Signature of Cancer: A Review from Warburg’s Time to Now

Résumé

This review focuses on the evolving understanding that we have of tumor cell metabolism, particularly glycolytic and oxidative metabolism, and traces back its evolution through time. This understanding has developed since the pioneering work of Otto Warburg, but the understanding of tumor cell metabolism continues to be hampered by misinterpretation of his work. This has contributed to the use of the new concepts of metabolic switch and metabolic reprogramming, that are out of step with reality. The Warburg effect is often considered to be a hallmark of cancer, but is it really? More generally, is there a metabolic signature of cancer? We draw the conclusion that the signature of cancer cannot be reduced to a single factor, but is expressed at the tissue level in terms of the capacity of cells to dynamically explore a vast metabolic landscape in the context of significant environmental heterogeneities.
Fichier principal
Vignette du fichier
Jacquet_Biomolecules_22.pdf (1.46 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03813369 , version 1 (05-11-2022)

Identifiants

Citer

Pierre Jacquet, Angélique Stéphanou. Searching for the Metabolic Signature of Cancer: A Review from Warburg’s Time to Now. Biomolecules, 2022, 12 (10), pp.1412. ⟨10.3390/biom12101412⟩. ⟨hal-03813369⟩
711 Consultations
38 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More