ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens constitute a threat to humans worldwide. We analyzed the rates of antimicrobial resistance in ESKAPE pathogens across India over the 2010-2020 decade after retrieving the data from the Medline PubMed repository using specific keywords. 89 studies that included 20,177 ESKAPE isolates showed that A. baumannii isolates were the most represented (35.9%, n = 7,238), followed by P. aeruginosa (25.3%, n = 5,113), K. pneumoniae (19.5%, n = 3,934), S. aureus (16.3%, n = 3,286), E. faecium (2.6%, n= 517) and Enterobacter spp. (0.4%, n = 89). A notable increase in the resistance rates to antimicrobial agents occurred over the 2010-20 decade. The most important levels of resistance were observed in 2016-20 for A. baumannii (90% of resistance to the amoxicillin-clavulanate combination) and K. pneumoniae (81.6% of resistance to gentamycin). The rise in beta-lactamase activities was correlated with an increase in the positivity of Gram-negative isolates for beta-lactamase genes. This review highlighted that, in contrast to developed countries that kept resistance levels under control, a considerable increase in resistance to various classes of antibiotics occurred in ESKAPE pathogens in India over the 2010-2020 decade.