The T-RAIG team (Translational Research in Autoimmunity and Inflammation Group) is a team accredited by the HCERES, created in 2021 and specialized in autoimmunity and inflammation.
It is co-directed by Professors Athan Baillet, rheumatologist, and Bertrand Huard, immunologist.
T-RAIG aims to federate a translational research on the Grenoble health site in partnership with several clinical departments including Rheumatology, Internal Medicine, Anatomopathology and Neurology.
T-RAIG projects are based on the study of chronic inflammatory processes leading to one human pathology.
Therapeutic targeting of plasma cells
Humoral immunity has to be targetted in autoimmunity. Recently, three B-cell directed therapies have been approved for clinical practice. Notably, none of these three directly targets antibody-producing plasmocytes, leaving unaffected established cells in treated patients. The long-term goal of this project is to identify target(s) expressed at the surface of plasmocytes in order to induce their depletion in an antibody-dependent manner. Our ambition is to find targets dependent of the microenvironment to enable us a organ/disease specific plasmocyte depletion.
Leaders: Bertrand Huard / Nathalie Sturm
Current funding:
- Société Française d’Hépatologie (AFEF) 2018-
- Fondation Française pour la Recherche contre le Myélome et les Gammopathies (FFRMG) 2021-2023
Neuronal regeneration in autoimmune diseases of the central nervous system
Excessive inflammation in autoimmune neurodegenerative diseases is nowadays well-controlled by highly specific immunosuppressive coumpounds. However, pro-regeneration drugs are crucially missing in the therapeutic arsenal. Our tissue approach in patients led us to discover that our long-term molecule of interest, a proliferation inducing ligand (APRIL), is a binding partner of the natural inhibitors of regeneration, the chondroitin sulfate proteoglycans (CSPG). This project aims at testing whether APRIL may antagonize CSPG inhibitory functions. The study concerns multiple sclerosis and neuromyelitis optica.
Leaders: Bertrand Huard / Olivier Casez
Current funding:
- Association pour la recherche contre la sclérose en plaques (ARSEP) 2020-2021
- Programme européen H2020 MSCA 2020-2023
- Agence nationale pour la recherche 2020-2022
Role of the neutrophil in spondyloarthritis
We study in the SKG mouse model of Chlamydia-induced reactive arthritisthe role of innate immunity cells, monocytes and neutrophils, in the onset of arthritis. The production of radical oxygen derivatives and cytokine by different cell types is analyzed
Leaders: Marie-Hélène Paclet / Athan Baillet
Current funding:
- TIMC laboratory - emergence program 2021
- Société française de rhumatologie 2020-2022
- Bourse Dreamer 2020-2022
Prediction of response to biotherapies in rheumatoid arthritis
We are evaluating the effecicay of a response prediction algorithm to rheumatoid arthritis biotherapies that combines several biomarkers identified by a proteomic approach.
Leaders: Philippe Gaudin / Athan Baillet
Current funding:
- European program H2020 EIT Health 2019-2021
TEAM MEMBERS PUBLICATIONS IN THE LAST THREE YEARS
Baert, L., M. Benkhoucha, N. Popa, M.C. Ahmed, B. Manfroi, J. Boutonnat, N. Sturm, G. Raguenez, M. Tessier, O. Casez, R. Marignier, M. Ahmadi, A. Broisat, C. Ghezzi, C. Rivat, C. Sonrier, M. Hahne, D. Baeten, R.R. Vives, H. Lortat-Jacob, P.N. Marche, P. Schneider, H.P. Lassmann, J. Boucraut, P.H. Lalive, and B. Huard. 2019. A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis. Ann. Neurol.
Belbézier, A., M. Arnaud, I. Boccon-Gibod, F. Pelletier, C. McAvoy, D. Gobert, O. Fain, A. Du-Thanh, D. Launay, J. Lupo, and L. Bouillet. 2021. COVID-19 as a trigger of acute attacks in people with hereditary angioedema. Clin Exp Allergy.
Casez, O., G. Willaume, S. Grand, B. Nemoz, J. Lupo, P. Kahane, and J.-P. Brion. 2021. Teaching NeuroImages: SARS-CoV-2-Related Encephalitis: MRI Pattern of Olfactory Tract Involvement. Neurology.
Drevet, S., G. Gavazzi, L. Grange, C. Dupuy, and B. Lardy. 2018. Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis. Exp Gerontol.
Labbé, C., N. Grima, T. Gautier, B. Favier, and J.A. Byrne. 2019. Semi-automated fact-checking of nucleotide sequence reagents in biomedical research publications: The Seek & Blastn tool. PLoS One.
Marceau, F., G.E. Rivard, J.M. Gauthier, K.E. Binkley, A. Bonnefoy, I. Boccon-Gibod, L. Bouillet, M. Picard, G. Levesque, H.L. Elfassy, H. Bachelard, J. Hébert, and K. Bork. 2020. Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants. Front Med (Lausanne).
Romand, X., X. Liu, M.A. Rahman, Z.A. Bhuyan, C. Douillard, R.A. Kedia, N. Stone, D. Roest, Z.H. Chew, A.J. Cameron, L.M. Rehaume, A. Bozon, M. Habib, C.W. Armitage, M.V.C. Nguyen, B. Favier, K. Beagley, M. Maurin, P. Gaudin, R. Thomas, T.J. Wells, and A. Baillet. 2021. Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice. Arthritis Rheumatol.
Trocmé, C., N. Gonnet, M. Di Tommaso, H. Samouda, J.-L. Cracowski, C. Cracowski, S. Lambert-Porcheron, M. Laville, E. Nobécourt, C. Gaddhab, A. Le Lay, T. Bohn, C. Poitou, K. Clément, F. Al-Mulla, M.S. Bitar, and S.P. Bottari. 2020. Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes? Front Mol Biosci.
Wendum, D., R. Layese, N. Ganne-Carrié, V. Bourcier, F. Merabtene, C. Cagnot, E. Sauce, N. Barget, P. Bedossa, B. Terris, J. Selves, P. Bioulac-Sage, N. Sturm, C. Sattonnet, P. Nahon, F. Roudot-Thoraval, M. Ziol, and ANRS CO12 CirVir Group. 2018. Influence of Progenitor-Derived Regeneration Markers on Hepatitis C Virus-Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort). Hepatology.
Zana, M., Z. Péterfi, H.A. Kovács, Z.E. Tóth, B. Enyedi, F. Morel, M.-H. Paclet, Á. Donkó, S. Morand, T.L. Leto, and M. Geiszt. 2018. Interaction between p22phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation. Free Radic Biol Med. 116:41–49. doi:10.1016/j.freeradbiomed.2017.12.031.
Team coordinator(s)
- Athan Baillet (Enseignant-Chercheur)
- Bertrand Huard (Enseignant-Chercheur)
Permanent members
- Athan BAILLET (Enseignant-Chercheur)
- Aude BELBEZIER (Chercheur)
- Laurence BOUILLET (Enseignant-Chercheur)
- Olivier CASEZ (Chercheur)
- Bertrand FAVIER (Enseignant-Chercheur)
- Philippe GAUDIN (Enseignant-Chercheur)
- Gaetan GAVAZZI (Enseignant-Chercheur)
- Dalil HANNANI (Chercheur)
- Bertrand HUARD (Enseignant-Chercheur)
- Salima KAMCHE (IT-BIATSS)
- Bernard LARDY (Enseignant-Chercheur)
- Marie Hélène PACLET (Enseignant-Chercheur)
- Nathalie STURM (Enseignant-Chercheur)
Others members
- Sabine DREVET (Enseignant-Chercheur contractuel)
- Sixtine GABOYER (Stagiaire)
- Louise GUET (Stagiaire)
- Arif KOCAK (Stagiaire)
- Baptiste LOBEY (Stagiaire)
- Mathias PEYROT (Stagiaire)
- Xavier ROMAND (Enseignant-Chercheur contractuel)
PhD students
- Nathan AYMARD (Doctorant)
- Aya CHAMAA (Doctorant)
- Zeineb CHEMKHI (Doctorant)
- Diane GIOVANNINI (Doctorant)
- Xavier Romand : " Role of innate immunity in spondyloarthritis. "
(supervised by Athan Baillet)
- Nathan AYMARD : "Exploration de l'interaction entre activité physique et sommeil dans les rhumatismes inflammatoires chroniques : effets d'une intervention combinée " (framed by Monique MENDELSON (CHU) , Patrice FLORE (CHU) , Athan BAILLET )
- Aya CHAMAA : "Etude du dialogue entre cellules de l’immunité innée dans le modèle murin SKG de spondyloarthrite " (framed by Xavier ROMAND (TIMC) , Bertrand FAVIER )
- Zeineb CHEMKHI : "Ciblage de modifications post-traductionnelles des plasmocytes pour le traitement des maladies autoimmunes " (framed by Bertrand HUARD )
- Diane GIOVANNINI : "Caractérisation des plasmocytes dans les tissus auto-immuns et allo-immuns. " (framed by Bertrand HUARD )
T-RAIG brings together a large number of research professors and hospital academics who are involved in teaching in the various departments of the University of Grenoble-Alpes. Some members of the team have key roles in learned societies, national clubs and clinical networks.
- Baillet Athan teaches rheumatology at the Faculty of Medicine.
- Bouillet Laurence teaches internal medicine at the Faculty of Medicine. She is also regional coordinator of the DES of internal medicine, and national coordinator of the national reference center of angiodemas.
- Casez Olivier teaches Neurology at the Faculty of Medicine. He is the referral physician for the national network on multiple sclerosis (ARSEP).
- Favier Bertrand teaches Biology at the Faculty of Sciences. He is a veterinarian referent for animal experimentation in Grenoble.
- Huard Bertrand teaches Immunology at the Faculty of Sciences. He is responsible for the MIDI (Microbiology, Infectious Diseases, Immunology) master's degree.
- Lardy Bernard teaches Biochemistry at the Faculty of Medicine and Pharmacy.
- Paclet Marie-Hélène teaches Biochemistry at the Faculty of Medicine and Pharmacy. She is co-founder of the French-speaking oxidase club.
- Sturm Nathalie teaches anatomopathology at the Faculty of Medicine. She is a member of the executive committee of the French Society of Pathology.
Valorisation
Start-up : SINNOVIAL
SINNOVIAL is a biotechnology company co-founded in September 2015 by Professors Athan Baillet and Philippe Gaudin. It focuses on the development of personalized medicine tools to improve the management of inflammatory diseases in rheumatology (rheumatoid arthritis, ankylosing spondylitis).
Patents
T-RAIG members hold 7 patents in areas including B-cell lymphoma, multiple sclerosis, personalized medicine for new biotherapiess.