Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments - Archive ouverte HAL
Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments

Marie Vasse 1 Sebastian Bonhoeffer 1 Antoine Frenoy 2 
2 TIMC-MAGe - Modèles et Algorithmes pour la Génomique
TIMC - Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525
Abstract : Abstract Stress is thought to increase mutation rate and thus to accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead to enhanced evolvability, thereby fuelling the adaptation of pathogens. Combining wet-lab experiments, stochastic simulations and a meta-analysis of the literature, we found that the increase in mutation rates triggered by antibiotic treatments is often cancelled out by reduced population size, resulting in no overall increase in genetic diversity. A careful analysis of the effect of ecological factors on genetic diversity showed that the potential for regrowth during recovery phase after treatment plays a crucial role in evolvability, being the main factor associated with increased genetic diversity in experimental data.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-03800374
Contributeur : Catherine ZOPPIS Connectez-vous pour contacter le contributeur
Soumis le : jeudi 6 octobre 2022 - 12:48:29
Dernière modification le : mardi 18 octobre 2022 - 04:31:30

Identifiants

Collections

Citation

Marie Vasse, Sebastian Bonhoeffer, Antoine Frenoy. Ecological effects of stress drive bacterial evolvability under sub-inhibitory antibiotic treatments. ISME Communications, 2022, 2 (1), pp.80. ⟨10.1038/s43705-022-00157-w⟩. ⟨hal-03800374⟩

Partager

Métriques

Consultations de la notice

33