Acclimatized Lowlanders Exhibit a Hypocoagulable Profile after a Passive Ascent at High Altitude - Archive ouverte HAL
Article Dans Une Revue High Altitude Medicine and Biology [High Altitude Medicine & Biology] Année : 2024

Acclimatized Lowlanders Exhibit a Hypocoagulable Profile after a Passive Ascent at High Altitude

Benoit Champigneulle

Résumé

Background: Discordant results have been previously reported regarding the impact of high-altitude (HA) exposure on coagulation. We aimed to investigate changes in coagulation parameters in lowlanders exposed to HA for 14&nbsp,days using a combination of dynamic coagulation assays and conventional in vitro tests.
Material and Methods: We assessed coagulation in 10&nbsp,lowlanders using whole-blood rotational thromboelastometry (ROTEM), thrombin generation assay (TGA) on poor-platelet plasma, and conventional coagulation tests. Tests were performed at low altitude (LA, 210 m) and at the end of a 14-day sojourn at HA, including passive ascents to 3,800 m for 6 days and then to 5,100 m for 8 days.
Results: Conventional tests revealed significant changes in coagulation factors and inhibitors after HA exposure, although these changes remained within normal ranges. ROTEM assays demonstrated a delayed clot initiation in EXTEM/FIBTEM, without any alteration in clot firmness, in HA versus LA (p < 0.01). TGA changes showed an increase in time to peak (p < 0.01), a decrease in endogenous thrombin potential (p < 0.05), and a decrease in thrombin peak (p < 0.001).
Conclusions: We found no evidence of hypercoagulability in lowlanders after a 14-day sojourn at HA. In contrast, dynamic coagulation assays (ROTEM and TGA) revealed a hypocoagulable pattern.

Domaines

Biotechnologies
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Dates et versions

hal-04916827 , version 1 (28-01-2025)

Identifiants

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Emeric Stauffer, François Caton, Raphael Marlu, Aurélien Pichon, Landry Seyve, et al.. Acclimatized Lowlanders Exhibit a Hypocoagulable Profile after a Passive Ascent at High Altitude. High Altitude Medicine and Biology [High Altitude Medicine & Biology], 2024, ⟨10.1089/ham.2024.0128⟩. ⟨hal-04916827⟩
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