Publications du laboratoire
Pregnancy and birth outcomes in women with multiple sclerosis: Comparison of the RESPONSE study to the general French population - Archive ouverte HAL
Article Dans Une Revue Multiple Sclerosis Journal Année : 2025

Pregnancy and birth outcomes in women with multiple sclerosis: Comparison of the RESPONSE study to the general French population

1 CHU Pitié-Salpêtrière [AP-HP]
2 HCL - Hospices Civils de Lyon
3 UCBL - Université Claude Bernard Lyon 1
4 OFSEP - Observatoire Français de la Sclérose En Plaques [Lyon]
5 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
6 Fondation Eugène Devic EDMUS
7 CIC - Centre d'Investigation Clinique [Rennes]
8 METIS - Département Méthodes quantitatives en santé publique
9 EHESP - École des Hautes Études en Santé Publique [EHESP]
10 ARENES - Arènes: politique, santé publique, environnement, médias
11 RSMS - Recherche sur les services et le management en santé
12 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
13 CHU Rouen
14 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
15 UM - Université de Montpellier
16 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
17 CRNL-FORGETTING - Forgetting Processes and Cortical Dynamics
18 CRNL-GenCyTi - Plateforme de Neurobiologie Moléculaire, Cellulaire et Tissulaire
19 MIRCEM - Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle
20 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
21 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
22 HUS - Les Hôpitaux Universitaires de Strasbourg
23 Service de Neurologie [CHRU Besançon]
24 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
25 Pôle NIRR - Service de Neurologie [CHU Nimes]
26 IGF - Institut de Génomique Fonctionnelle
27 CHU Dijon
28 CEP - Centre d'épidémiologie des populations
29 Service de Neurologie [CHU Caen]
30 LilNCog - Lille Neurosciences & Cognition - U 1172
31 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
32 Service de Neurologie [CHU Rennes]
33 CHU Clermont-Ferrand
34 Neuro-Dol - Neuro-Dol
35 CRC-SEP Auvergne - Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Clermont-Ferrand]
36 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
37 TIMC-T-RAIG - Translational Research in Autoimmunity and Inflammation Group
38 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
39 CIC Plurithématique de Nantes
40 U1064 Inserm - CR2TI - Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology
41 UCL - Université catholique de Lille
42 Centre Hospitalier Métropole Savoie [Chambéry]
43 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
44 CHU de Bordeaux Pellegrin [Bordeaux]
45 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
46 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
47 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
48 Centre Hospitalier d'Annecy Genevois
49 CHU - Hôpital Pasteur [Nice]
50 UR2CA URRIS - UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées
Elisabeth Maillart
  • Fonction : Auteur
  • PersonId : 1516278
Bertrand Bourre
  • Fonction : Auteur
Kumaran Deiva
Saskia Bresch
  • Fonction : Auteur

Résumé

Background: Retrospective studies did not show strong evidence of higher risk of adverse neonatal or pregnancy outcomes in women with multiple sclerosis (MS) compared to general population, but there are contradictory data on prematurity, cesarean section, and small birthweight for gestational age (SGA). Methods: We compared pregnancy and birth outcomes in MS women included in RESPONSE, a French prospective cohort, with a recent survey (Enquête Nationale Périnatale (ENP)) describing leading indicators in perinatal epidemiology in France. Results: On 7 April 2023, 476 pregnancies (461 MS women, 482 expected newborns) from RESPONSE were available. The ENP study reported 12,723 women and 12,939 expected newborns in March 2021. MS patients were older (mean age 32.6 ± 4.4 vs. 30.9 ± 5.3 years, p < 0.001), with similar rate of cesarean (23.8% vs. 21.4%, p = 0.115) and use of locoregional analgesia (86.6% vs. 85.1%, p = 0.51). Preterm birth was less frequent (4.0% vs. 7.0%, p = 0.001). Birthweight of children from MS mothers was similar to general population (3240 ± 477.2 vs. 3264.5 ± 552.9 g, p = 0.22), with slightly more children with SGA (13.4% vs. 9.8%, p = 0.04). Conclusion: This prospective and contemporary comparison of pregnancy in MS women and the French population provides reassuring results. In the future, we need to assess the impact of disease-modifying treatment exposure during conception.

Fichier non déposé

Dates et versions

hal-05000197 , version 1 (21-03-2025)

Identifiants

Citer

Elisabeth Maillart, Fabien Rollot, Emmanuelle Leray, Lakhdar Benyahya, Bertrand Bourre, et al.. Pregnancy and birth outcomes in women with multiple sclerosis: Comparison of the RESPONSE study to the general French population. Multiple Sclerosis Journal, 2025, 31 (3), pp.324 - 337. ⟨10.1177/13524585251316474⟩. ⟨hal-05000197⟩
37 Consultations
0 Téléchargements

Altmetric

Partager

  • More