Nanostructural characterization of the tumor biomarker Alpha-Fetoprotein interacting with model cellular membranes
Résumé
This study systematically investigated the interactions of the tumor biomarker alpha-fetoprotein (AFP) and bovine serum albumin (BSA) with planar lipid membranes using neutron reflectometry, quartz crystal microbalance with dissipation monitoring, and atomistic molecular dynamics simulations. By examining a range of lipid compositions-including charged, neutral, and nanodomain-containing bilayers-we dissected the molecular mechanisms governing protein-membrane interactions. AFP consistently exhibited stronger interactions than BSA. While both proteins showed negligible binding to.
Domaines
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