An integrative model of the self-sustained oscillating contractions of cardiac myocytes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Acta Biotheoretica Année : 2005

An integrative model of the self-sustained oscillating contractions of cardiac myocytes.

A. Pustoc'H
  • Fonction : Auteur
Jacques Ohayon
  • Fonction : Auteur
  • PersonId : 951674
Yves Usson
Alain Kamgoué
  • Fonction : Auteur
Philippe Tracqui
  • Fonction : Auteur

Résumé

Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are well documented and modelled, a simple enough virtual cell taking into account the mechano-chemical coupling between calcium oscillations and cell mechanical properties is still lacking. Considering the spontaneous periodic contraction of isolated cardiac myocytes, we propose here a virtual cardiac cell model in which the cellular contraction is modelled using an hyperelastic description of the cell mechanical behaviour. According to the experimental data, the oscillating cytosolic calcium concentrations trigger the spatio-temporal variation of the anisotropic intracellular stresses. The finite element simulations of the virtual cell deformations are compared to the self-sustained contractions of isolated rat cardiomyocytes recorded by time-lapse video-microscopy.

Domaines

Imagerie
Fichier non déposé

Dates et versions

hal-00078474 , version 1 (06-06-2006)

Identifiants

Citer

A. Pustoc'H, Jacques Ohayon, Yves Usson, Alain Kamgoué, Philippe Tracqui. An integrative model of the self-sustained oscillating contractions of cardiac myocytes.. Acta Biotheoretica, 2005, 53 (4), pp.277-93. ⟨10.1007/s10441-005-4880-5⟩. ⟨hal-00078474⟩
736 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More