Continuous Endogenous Exhaled CO Monitoring by Laser Spectrometer in Human EVLP Before Lung Transplantation - Archive ouverte HAL
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Continuous Endogenous Exhaled CO Monitoring by Laser Spectrometer in Human EVLP Before Lung Transplantation

Abstract : Endogenous production of carbon monoxide (CO) is affected by inflammatory phenomena and ischemia-reperfusion injury. Precise measurement of exhaled endogenous CO (eCO) is possible thanks to a laser spectrometer (ProCeas® from AP2E company). We assessed eCO levels of human lung grafts during the normothermic Ex-Vivo Lung Perfusion (EVLP). ProCeas® was connected in bypass to the ventilation circuit. The surgical team took the decision to transplant the lungs without knowing eCO values. We compared eCO between accepted and rejected grafts. EVLP parameters and recipient outcomes were also compared with eCO values. Over 7 months, eCO was analyzed in 21 consecutive EVLP grafts. Two pairs of lungs were rejected by the surgical team. In these two cases, there was a tendency for higher eCO values (0.358 ± 0.52 ppm) compared to transplanted lungs (0.240 ± 0.76 ppm). During the EVLP procedure, eCO was correlated with glucose consumption and lactate production. However, there was no association of eCO neither with edema formation nor with the PO 2 /FiO 2 ratio per EVLP. Regarding post-operative data, every patient transplanted with grafts exhaling high eCO levels (>0.235 ppm) during EVLP presented a Primary Graft Dysfunction score of 3 within the 72 h post-transplantation. There was also a tendency for a longer stay in ICU for recipients with grafts exhaling high eCO levels during EVLP. eCO can be continuously monitored during EVLP. It could serve as an additional and early marker in the evaluation of the lung grafts providing relevant information for post-operative resuscitation care.
Liste complète des métadonnées

https://hal.archives-ouvertes.fr/hal-03767330
Contributeur : Daniele Romanini Connectez-vous pour contacter le contributeur
Soumis le : jeudi 22 septembre 2022 - 15:04:05
Dernière modification le : mercredi 28 septembre 2022 - 04:44:22

Fichier

ti-35-10455.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Vivien Brenckmann, Raphael Briot, Irène Ventrillard, Daniele Romanini, Maud Barbado, et al.. Continuous Endogenous Exhaled CO Monitoring by Laser Spectrometer in Human EVLP Before Lung Transplantation. Transplant International, Wiley, 2022, 35, ⟨10.3389/ti.2022.10455⟩. ⟨hal-03767330⟩

Partager

Métriques

Consultations de la notice

0

Téléchargements de fichiers

0