Multi-omics analysis Sampling Sampling modules release Passing through the stomach Characterization of the small human intestinal microbiome using an innovative medical device
Résumé
The gut microbiome (microbial community with distinct physio-chemical properties in a given habitat 1 ) → major role in maintaining health.
• Stratification through the gastrointestinal tract (micro-organisms and metabolites) (Figure 1).
• Dysbiosis = unbalanced microbiome → linked to some cancers, inflammatory, metabolic and neurological diseases… • Current methods for the study of the human intestinal microbiome: not representative of the entire gut microbiome.
• Faecal analysis: common but do not fully represent the intestinal microbiome (only large bowel).
• Endoscopy and colonoscopy: expensive, invasive and complex to implement on a large scale. Could introduce a contamination bias during collection 2 .
To overcome these issues, PELICAN HEALTH develops a cutting-edge ingestible device, able to perform multi-sampling in the small intestine (SI) to perform multi-omics analysis (Figure 2).
Domaines
| Origine | Fichiers produits par l'(les) auteur(s) |
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