• The gut microbiome (microbial community with distinct physio-chemical properties in a given habitat 1 ) → major role in maintaining health. • Stratification through the gastrointestinal tractus (micro-organisms and metabolites) (Figure 1).

• Dysbiosis = unbalanced microbiome → linked to some cancers, inflammatory, metabolic and neurological diseases.

• Current methods for the study of the human intestinal microbiome: not representative of the entire gut microbiome.

• Faecal analysis: common but do not fully represent the intestinal microbiome (only large bowel).

• Endoscopy and colonoscopy: expensive, invasive and complex to implement on a large scale. Could introduce a contamination bias during collection 2 .

To overcome these issues, PELICAN HEALTH develops a cutting-edge MEMS free ingestible device, able to perform multisampling in the small intestine to perform multi-omics analysis (Figure 2).