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Introduction team

SyNaBi is a dynamic research team with a focussed thematic axis in biological engineering.

Scientific theme and general objectives

SyNaBi is a dynamic research team with a focused thematic axis in biological engineering. Our primary objective is to conduct fundamental research to investigate the role of biological molecules (e.g., enzymes, proteins) in
various applications, including lipid bilayers, biosensors, biomimetic cell systems, and drug delivery systems. Our research endeavors span from the nanoscale to the microscale and macroscale, enabling us to gain comprehensive insights into these complex systems. To achieve this multidimensional exploration, the SyNaBi team harnesses its core expertise in electrophysiology, biophysics, large-scale facililities (neutron and X-ray scattering), bioelectrochemistry, opto-acoustic intravital microscopy, biopolymers, drug delivery, and cell/molecular biology.

SyNaBi utilizes its core expertise and knowledge to develop various types of medical devices. One common
physiological challenge faced by these devices is their response when in contact with body tissues. SyNaBi
addresses these issues by creating biological engineering solutions based on the results of our fundamental
research.

Our contributions to the field extend beyond academic publications in renowned journals. SyNaBi actively engages in patenting medical devices, which has led to the successful establishment of startups like Pelican Health SAS, The Element Biotechnology SAS, and WatPill SAS.

To support our ambitious pursuits, we continuously secure research grants, dedicated not only to fundamental research but also to fostering the maturation and incubation of projects. These initiatives serve as the foundation for future startups and other cutting-edge advancements in drug delivery and medical innovations.

 

 

Research Programs
Research Programs

 Currently Funded Research (2023 - )

FUNDING AGENCY PROJECT ACRONYM
ANR Azotics
ANR IMAGin
European Commission InnovaXN
SATT / Linksium UROLOC
SATT / Linksium BioPic
SATT / Linksium Endobiocrine
Région Rhône Alpes Enteroprobe
Région Rhône Alpes ENZYFLOW
CNRS Pre-Maturation BEPI
CNRS Pre-Maturation BIOPEPC
CNRS / INSIS ALIX
Carnot LSI BIOEPC
Carnot LSI NeuroMorph

 

Research Grants before 2022

  • ANR - projet BIOWATTS
  • ANR - projet IMABIC
  • SATT - projet BIOPILE
  • SATT - projet MICROBIOTE SAMPLER
  • SATT - projet MODULATEUR MICROBIOTE
  • Ligue Contre le Cancer - projet VE-Cadherin  / phospholipids
  • ValoGRAL - projet UroLOC

Research Grants 2011-2016

  • Investissement d’Avenir - projet IBFC 
  • ANR - projet BROCOLI
  • ANR - projet M-GBFC
  • Horizon 2020 - projet UroLOC (complementary list)
  • AGIR-UGA - projet MEKANO

Subvention LIGUE

Supervisor(s): Donald MARTIN
Contract: LA LIGUE CONTRE LA CANCER Isère - CNRS - [2017-2018]
Nanobiotechnology utilized in the search for better understanding of interactions between cancer biomarkers et lipoproteins.

Projet pré-maturation start-up BIOPILE

Power from the body for the body
Supervisor(s): Philippe CINQUIN
Contract: SATT Linksium, Technology transfer and startup building Grenoble Alpes - UNIVERSITE GRENOBLE ALPES - [2015-2017]
We have designed an enzymatic biofuel cell that uses glucose from the body to produce power for implantable devices. The biofuel cell is original in its method of production and its use of bioinspired solutions to overcome biocompatibility hurdles.
Project Page

Projet MICROBIOTA

Supervisor(s): Donald MARTIN
Contract: SATT Linksium, Technology transfer and startup building Grenoble Alpes - UNIVERSITE GRENOBLE ALPES - [2017-2018]

LIGUE

Supervisor(s): Donald MARTIN
Contract: LA LIGUE CONTRE LA CANCER Isère - CNRS - [2017-2018]

Projet IMABIC

Supervisor(s): Abdelkader ZEBDA
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-16-CE19-0007) - UNIVERSITE GRENOBLE ALPES - [2016-2021]
Implantable Abiotic Biofuel Cell.
Project Page

Projet bioWATTS

Supervisor(s): Donald MARTIN
Contract: AGENCE NATIONALE DE LA RECHERCHE (ANR-15-CE05-0003) - UNIVERSITE GRENOBLE ALPES - [2015-2019]
Biomimetic membranes that produce biologically-inspired energy.
Project Page

Projet BIOPILE

Supervisor(s): Philippe CINQUIN
Contract: SATT Linksium, Technology transfer and startup building Grenoble Alpes - UNIVERSITE GRENOBLE ALPES - [2015-2017]

Projet TAENIA artificiel

Supervisor(s): Philippe CINQUIN
Contract: Convention de reversement CNRS - UNIVERSITE GRENOBLE ALPES - [2015-2017]
Team members

Team coordinator(s)

Permanent members

Others members

PhD students

Anciens membres de l'equipe

  • Barry Stidder (Postdoc)
  • Lavinia Liguori (Postdoc)
  • Landry Gayet (Postdoc)
  • Sarra El Ichi (Postdoc)
  • Geraldine Penven (PhD)
  • Thomas Soranzo (Postdoc)
Thesis

Synabi PhD thesis :

  • Béatrice BARLETTI : "Caractérisation nanostructurale des interactions protéiques avec les membranes bicouches lipidiques : base pour le développement de biocapteurs " (framed by Marco MACCARINI )
  • Thomas LECOURT : "Optimization of gold nanostructures electrodeposition for implantable enzymatic glucose biofuel cells " (framed by Abdelkader ZEBDA , MARC ZELSMANN (LTM UMR5129) )
  • Meryem RAOUDI : "Optimisation du procédé de broyage de Serenoa Repense, développement des méthodes d'extraction et d'identification des principes actifs et formulation d'une forme pharmaceutique. " (framed by Abdelaziz BAKRI )
  • Alexandre TRONEL : "Formulation de conservateurs du liquide intestinal du grêle à des fins d'analyses méta-omiques; implémentation sous forme anhydre dans des dispositifs de prélèvement non-invasifs ingérables " (framed by Donald MARTIN , Audrey LE GOUELLEC , Thomas SORANZO (Pelican Health) )
Platforms - Resources
Plateforme de Microscopie IntraVitale
Intravitale


La microscopie intravitale est outil qui permet d'analyser le fonctionnement des cellules saines ou malades dans un environnement complexe du vivant, avec la (patho)physiologie et la biologie tissulaire, cellulaire et moléculaire intacte. Pour obtenir ces informations complexes, un savoir faire unique a été développé sur la PF depuis 2002.

Notre mission est de réaliser des protocoles concernant la technique de microscopie optique, le traitement et l'analyse des images, permettant de comprendre comment les changements cellulaires, tissulaires et vasculaires évoluent dans le cadre d'un diagnostic et le suivi d'un traitement.

 


  Équipements :

  Informations plateforme

  • (à venir)

 

Responsable scientifique :

BvdSanden  Boudewijn van der Sanden

 boudewijn.vandersanden [at] univ-grenoble-alpes.fr
 06 48 54 67 12
 

 Intravitale

La plateforme (PF) a été labellisée par GiS-IBiSA en 2007 et France Life Imaging en 2012.

 

Primary collaborations and grants

National collaborations

  • In Grenoble :
    • CEA (iSTRV/BGE, LETI, INAC)
    • ILL (Institut Laue Langevin)
    • LGP2
    • LRB
  • in France :
    • Université de Clermont Ferrand
    • ICBMS Lyon
    • Creancey
    • Paris HEGP
  

International collaborations

University of East Anglia, Norwich Medical School (U.K.). MESA+ Institute for Nanotechnology. University of Twente (The Netherlands). Tyndall National Institute (Ireland), University of Turku (Finland). University of Melbourne (Australia)

Industrial collaborations

  • France : Synthelis SAS, Sorin Group, Biopic SAS. ST Microelectronics, Groupe Absiskey - Vitamib, 
  • International : Creamedix GmbH (Allemagne), Mosaiques Diagnostics GmbH (Allemagne),0stendum R&D b.v. (Pays-BAS), Seagull Technologies Pty Ltd (Australie), SDX Tethered Membrancs Pty Ltd (Australie)
Teaching-Training

Donald Martin

  • responsible of UE MCMB7U00 "Outils Moléculaires en Santé" de M1 Ingénierie pour la Santé /Science et Management des Biotechnologies (SMB)
  • responsible of UE MCXA0008 UE "Micro and Nanotechnologies for Health" de Master 2 ISM
  • is teaching in UE ‟Biosensors and high throughput analysisˮ - 5PMBBTA7 Grenoble INP Phelma

Contact

don.martin-at-univ-grenoble-alpes.fr
Phone: 00 33 456 52 00 95
Address: Faculté de Médecine de Grenoble, Pavillon Taillefer, 38706 La Tronche